AI-850
AI-850 is Acusphere's patented formulation of paclitaxel, the active ingredient in the cancer drugs, Taxol® (Bristol-Myers Squibb Company) and Abraxane® (Celgene Corporation). AI-850, is a cremaphor-free formulation of paclitaxel. Cremaphor is an oil used in the Taxol formulation to dissolve paclitaxel. Because of the Cremaphor, Taxol has many side effects that require premedication and it must be infused slowly over a three hour period. AI-850 eliminates the side effects associated with Cremaphor and can be injected as a bolus. The worldwide rights to AI-850 were licensed to Cephalon in 2008.